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Careers

Employment Opportunities in Molecular Biology

The Neural Stem Cell Institute is seeking highly motivated candidates to work in research labs dedicated to studying vision or degenerative diseases of the nervous system. These positions will provide on-the-job training for the right individuals. Primary responsibilities will be supporting the research in the lab.

Responsibilities include but are not limited to:

  • Assist in conducting research experiments using techniques such as basic molecular biology (bacterial cell culture, bacterial cell transformation, plasmid DNA preparation), PCR amplification of genomic and plasmid DNA, and light microscopy;
  • Assisting in the maintenance of cell lines, including human pluripotent stem cells;
  • Prepare and maintain stock solutions;
  • Maintain lab notebook and electronic records;
  • Analyze data using computer software and statistical methods;
  • Assist with data preparation for publication;
  • Follow lab safety protocols;
  • Learn and master new techniques and procedures as needed.

Required Qualifications:  Bachelor’s degree in biology, genetics, molecular biology, biochemistry, or cell biology, or related subject.

  • Must be personable, flexible, proactive, demonstrated a positive “can do” attitude, possess excellent organizational and communication skills and take pride in their work.
  • Ability to develop effective working relationships with students, faculty, and staff.
  • Ability to maintain a comprehensive, up to date, and accurate research lab notebook. Visual concentration, attention to detail and manual dexterity are required.
  • Must be willing to learn new laboratory skills.
  • Must be able to work independently as well as in a team environment to accomplish the required tasks.
  • Should be comfortable with basic computer programs such as MS Word and Excel.
  • Able to work under general supervision and proceed alone on regular tasks.

Preferred Qualifications: Familiar with basic molecular biological, cell biological, biochemical techniques and/or sterile cell culture techniques.

Applications will be accepted until a suitable candidate has been selected. To be considered, please submit BOTH cover letter and resume to nsci-hr@neuralsci.org. No visa sponsorship or relocation assistance is provided for this position.

 

Postdoctoral Fellow Opportunity

The Neural Stem Cell Institute (NSCI) is seeking Postdoctoral Fellow to join the laboratory to develop novel intracellular antibody (intrabody) therapeutics for neurodegenerative disorders.

Research: Several diverse neurodegenerative diseases share the common molecular pathway of protein misfolding, generating toxic species, triggering a pathogenic cascade within the central nervous system (CNS). The long-term goal of this research program is to develop immunotherapeutics that provide protection against neurodegenerative disorders due to protein misfolding. Our central hypothesis is that targeted degradation of huntingtin, synuclein, and tau protein through the cells’ normal protein clearing process will reduce the bioavailability of these proteins available to misfold, thus reducing cellular toxicity. Projects will utilize recombinant antibody technologies to develop novel bifunctional intrabody reagents specifically targeting and preventing the misfolding of putative neurodegenerative proteins and directing them into the cells’ normal protein clearance pathways in induced pluripotent stem cell (iPSC) derived neurons, recapitulating disease phenotypes observed in the human brain. Experiments will involve the use of recently developed CRISPR Tau iPSCs, cutting-edge cell and molecular biology techniques including tissue culture, in vitro differentiation of iPSCs, RNASeq/single cell transcriptome analysis, chromatin immunoprecipitation, FACS sorting, and immunofluorescence.

 Institute:  NSCI is a state-of-the-art research facility in the NYS Capital District.  The successful applicant will join a vibrant research environment with diverse projects focused on nervous system development, disease, and repair. NSCI is dedicated to building a diverse community and is an equal opportunity employer.

Requirements

Qualifications:  The position is for a highly motivated seeking an independent research career.

The ideal applicant will possess:

  • Assist in conducting research experiments using techniques such as basic molecular biology (bacterial cell culture, bacterial cell transformation, plasmid DNA preparation), PCR amplification of genomic and plasmid DNA, and light microscopy.
  • A strong background in developmental and stem cell biology. Experience in genetic engineering, flow cytometry, confocal microscopy, RNAseq/ChIPseq, advanced molecular biology, genomic data analysis, and mammalian cell culture are highly desirable.
  • The ability to work independently, show initiative and attention to detail, and the motivation to explore new techniques and concepts.
  • Candidates can expect active mentorship, and a positive and success-oriented work environment.

Apply: Applications will be accepted until the position is filled.  Interested applicants should email a cover letter and CV, complete contact information for 3 references, and a career statement (1-2 pages) to nsci-hr@neuralsci.org.