Regenerative Eye Research- More Than Meets the Eye

Breakthroughs in Regenerative Eye Research Closer Than You Think

RENSSELAER N.Y., June 08, 2018 – As the field of regenerative medicine has progressed to deliver breakthroughs throughout medicine; leading discoveries have been made in ophthalmology. A recent article published in Cell Stem Cell (Volume 22, Number 6), Regenerating Eye Tissues to Preserve and Restore Vision, written by Drs. Jeffrey Stern and Sally Temple of the Neural Stem Cell Institute (NSCI) and colleagues, reviews major milestones in ophthalmic regenerative medicine to transform the treatment of diverse eye diseases including corneal disease, glaucoma, cataract, and age-related macular degeneration. “The eye has become a focus for Stem Cell therapy,” said Dr. Sally Temple, the Scientific Director of NSCI in Rensselaer, NY. This review highlights emerging therapies such as transplantation of stem cells for eye repair, the use of synthetic biocompatible materials and natural scaffolds with cells delivered to the eye, and activation of endogenous eye stem cells.  While stem-cell based regenerative therapies for eye diseases range from transplantation to coaxing in situ stem cells to regenerate defective tissue, the novel regenerative therapies raise new challenges about how to make therapies available to patients and how the patients’ immune system will respond. Future strategies to overcome these challenges include matching stem cell transplants to patients to mitigate rejection; optimizing cell product manufacturing for safe and adequate supply, and establishing sound regulation to curb the spread of unapproved “therapies” that have caused tragic outcomes. Cell Stem Cell also featured the cover art by co-author Tian Isabel Yangzi submitted with the review.

Click here to read the original article:

About NSCI: The Neural Stem Cell Institute (NSCI) is a non-profit 501(c)(3) organization and the first independent, neural stem cell research institute in the United States. Headquartered at the East Campus of the University at Albany in Rensselaer, NY, NSCI is a unique organization that produces leading stem cell research to develop new therapies for diseases of the central nervous system such as Alzheimer’s disease, Parkinson’s disease, and Age-related Macular Degeneration. NSCI aims to harness the power of stem cells to ease the suffering caused by injury and disease of the brain, spinal cord, and retina. NSCI has over 30 individuals focused on finding new ways to promote nervous system repair and has published numerous articles on groundbreaking stem cell discoveries and their implications for neural disease cures. For additional information, visit

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Addressing unregulated stem cell treatment centers

In recent years hundreds of unregulated stem cell treatment centers have cropped up across the U.S. These clinics claim to offer treatments for a wide variety of diseases and ailments by using patients’ own stem cells. These centers often use high-pressure sales tactics to prey on individuals and families who are desperate for cures. All the while, the ongoing use of these questionable and unproven practices risk poisoning the public’s good will and could jeopardize legitimate research programs whose results may still be years away.

In a recent article the Washington Post details the experiences of one individual who lost her vision after one such treatment. This is a highly recommended read that also highlights the work of attorney Andrew Yaffa in pursuing these dubious centers as well as comments from our founder Sally Temple.

Read the article at the Washington Post

New FDA designation opens the door for stem cell trials

Dr. Temple contributed to a recent article on a stem cell clinical trial that has recently received the Food and Drug Administration’s new Regenerative Medicine Advanced Therapy (RMAT) designation.

Read more about how this new designation will help to promote the advancement of legitimate stem cell therapies:–Antibody-Engineering/

Dr. Messer hosts webinar for “The Scientist”

Dr. Anne Messer was one of two experts chosen to present a webinar for The Scientist (March 8, 2018.) Antibodies are the fastest growing class of synthetic therapeutics, and Dr. Messer’s presentation covered their development and use as therapeutics and markers for neurodegenerative diseases. She described cutting-edge design and optimization approaches, as well as offering insight on future directions in antibody engineering. Human stem cell lines and assays at NSCI allow screening and testing for which of these engineered antibodies and their variants should be carried forward as clinical drug candidates. The session had 581 registrants and 148 live viewers who also asked questions at the end of the presentations.–Antibody-Engineering/

Support NSCI on November 28th, #GivingTuesday


Celebrate your kindness on #GivingTuesday.

On #GivingTuesday, a national day of donation, consider a gift to the Neural Stem Cell Institute. Your gift gets us closer to therapies for incurable diseases of the central nervous system including Macular Degeneration, Alzheimer’s, Parkinson’s, Spinal Cord Injury and Autism. Your support inspires our ongoing research and brings us closer to cures.

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